RT Journal Article SR Electronic T1 Clinicopathological Significance of MTUS1 Expression in Patients With Renal Cell Carcinoma JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 2961 OP 2967 DO 10.21873/anticanres.14275 VO 40 IS 5 A1 JONGMIN SIM A1 YOUNG CHAN WI A1 HA YOUNG PARK A1 SUNG YUL PARK A1 YOUNG EUN YOON A1 SEONGSIK BANG A1 YESEUL KIM A1 KISEOK JANG A1 SEONG SAM PAIK A1 SU-JIN SHIN YR 2020 UL http://ar.iiarjournals.org/content/40/5/2961.abstract AB Background/Aim: Microtubule-associated tumor suppressor 1 (MTUS1) is a novel tumor suppressor involved in proliferation and migration, and down-regulation of MTUS1 is associated with the poor prognosis of several cancers. We evaluated the clinicopathological significance of MTUS1 expression in renal cell carcinoma (RCC). Patients and Methods: We assessed MTUS1 expression by immunohistochemical staining of tissue microarrays from 249 cases of RCC. We analyzed the correlation of MTUS1 expression and clinicopathological characteristics. Additionally, we used public databases and performed bioinformatics analysis. Results: We investigated The Cancer Genome Atlas databases and identified that MTUS1 mRNA expression was significantly lower in RCC tissues than in normal tissues. Loss of MTUS1 expression was correlated with high WHO/ISUP nuclear grade, lymphovascular invasion, renal vein thrombus, and high pT stage in patients with RCC. Although there was no statistically significant correlation between MTUS1 expression and patients' prognosis in our cohort, MTUS1 overexpression was significantly correlated with a favorable prognosis in public data. Conclusion: Loss of MTUS1 expression in RCC might be a potential biomarker for predicting clinical outcome.