RT Journal Article
SR Electronic
T1 Urinary Tract Large Cell Neuroendocrine Carcinoma: Diagnostic, Prognostic and Therapeutic Issues
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 2439
OP 2447
DO 10.21873/anticanres.14213
VO 40
IS 5
A1 FRANCESCA SANGUEDOLCE
A1 BEPPE CALÒ
A1 MARCO CHIRICO
A1 SIMONA TORTORELLA
A1 GIUSEPPE CARRIERI
A1 LUIGI CORMIO
YR 2020
UL http://ar.iiarjournals.org/content/40/5/2439.abstract
AB Large cell neuroendocrine carcinoma (LCNEC) of the urinary tract is a high-grade neuroendocrine tumor with distinct pathological features, usually portending an aggressive clinical behavior in comparison to conventional urothelial carcinoma. Due to its low prevalence, little is known about its clinical management and there is no current standard of care. The aim of this review was to summarize the current knowledge about LCNEC of the bladder, ureter and kidney, with relevance to diagnostic, prognostic and therapeutic issues, through a systematic analysis of clinical, pathological and outcome data retrieved from the literature.