TY - JOUR T1 - Urinary Tract Large Cell Neuroendocrine Carcinoma: Diagnostic, Prognostic and Therapeutic Issues JF - Anticancer Research JO - Anticancer Res SP - 2439 LP - 2447 DO - 10.21873/anticanres.14213 VL - 40 IS - 5 AU - FRANCESCA SANGUEDOLCE AU - BEPPE CALĂ’ AU - MARCO CHIRICO AU - SIMONA TORTORELLA AU - GIUSEPPE CARRIERI AU - LUIGI CORMIO Y1 - 2020/05/01 UR - http://ar.iiarjournals.org/content/40/5/2439.abstract N2 - Large cell neuroendocrine carcinoma (LCNEC) of the urinary tract is a high-grade neuroendocrine tumor with distinct pathological features, usually portending an aggressive clinical behavior in comparison to conventional urothelial carcinoma. Due to its low prevalence, little is known about its clinical management and there is no current standard of care. The aim of this review was to summarize the current knowledge about LCNEC of the bladder, ureter and kidney, with relevance to diagnostic, prognostic and therapeutic issues, through a systematic analysis of clinical, pathological and outcome data retrieved from the literature. ER -