PT  - JOURNAL ARTICLE
AU  - DIRK RADES
AU  - TRANG NGUYEN
AU  - MAI TRONG KHOA
AU  - STEFAN JANSSEN
AU  - STEVEN E. SCHILD
TI  - Evaluation of Five Survival Scores in a Cohort of Elderly Patients With Cerebral Metastasis from Non-small Cell Lung Cancer
AID  - 10.21873/anticanres.14259
DP  - 2020 May 01
TA  - Anticancer Research
PG  - 2847--2851
VI  - 40
IP  - 5
4099  - http://ar.iiarjournals.org/content/40/5/2847.short
4100  - http://ar.iiarjournals.org/content/40/5/2847.full
SO  - Anticancer Res2020 May 01; 40
AB  - Background/Aim: Survival scores are important for treatment personalisation. A score for older patients with cerebral metastasis from non-small cell lung cancer (NSCLC) was generated. Patients and Methods: Dose-fractionation of whole-brain irradiation, age, gender, general condition, histology, count of cerebral lesions, extra-cerebral metastatic spread and time between NSCLC-diagnosis and whole-brain irradiation were analysed for survival in 285 patients. Independent prognostic characteristics were utilised for the score, which was compared against five others. Results: Based on general condition (p<0.001) and extra-cerebral spread (p=0.003), three groups were generated according to the score, 2 (n=49), 4-6 (n=206) and 7 (n=30) points. Positive predictive values (PPVs) to predict death ≤6 months and survival for ≥6 months were 100% and 52%, respectively. PPVs of other scores were 88-98% and 60-63%. Conclusion: The accuracy of the new score to predict death within ≤6 months was optimal, whereas its accuracy to predict survival for ≥6 months was lower when compared to the other low PPVs of existing scores.