RT Journal Article
SR Electronic
T1 Primary Peritoneal High-grade Serous Carcinoma Misinterpreted as Metastatic Breast Carcinoma: A Rare Encounter in Peritoneal Fluid Cytology
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 2933
OP 2939
DO 10.21873/anticanres.14271
VO 40
IS 5
A1 SUJIN PARK
A1 EUN YOON CHO
A1 YOUNG LYUN OH
A1 YEON HEE PARK
A1 HYUN-SOO KIM
YR 2020
UL http://ar.iiarjournals.org/content/40/5/2933.abstract
AB Background/Aim: Peritoneal fluid (PF) cytology is critical for distinguishing high-grade serous carcinoma (HGSC) from metastatic disease in patients with breast carcinoma who present with peritoneal carcinomatosis (PC). Case Report: A 50-year-old woman underwent surgery and adjuvant therapy for pT1N0 grade 2/2 luminal A breast carcinoma. Sixteen months postoperatively, palliative chemotherapy was administered following a pleural biopsy and diagnosis of metastatic carcinoma. The patient developed PC despite chemotherapy. PF cytology specimens suggested metastatic carcinoma. However, we observed a papillary cellular arrangement during the review of cytology slides. HGSC was confirmed by immunocytochemistry showing positive paired box 8 (PAX8) and Wilms' tumor 1 (WT1) expression and negative GATA-binding protein 3 expression. Conclusion: In patients with breast carcinoma history, an awareness of characteristic cytomorphology of HGSC, including a papillary pattern with positive PAX8 and WT1 immunoreactivity, is essential to prevent the misdiagnosis of such cases and in ensuring accurate treatment and management.