TY - JOUR T1 - Urethane-induced Mammary Carcinogenesis Susceptibility in Transgenic Mice Expressing a Dominant-negative TGF-β Type II Receptor JF - Anticancer Research JO - Anticancer Res SP - 2687 LP - 2694 DO - 10.21873/anticanres.14239 VL - 40 IS - 5 AU - MASA-AKI SHIBATA AU - EIKO SHIBATA AU - JUNJI MORIMOTO AU - YOICHI KONDO Y1 - 2020/05/01 UR - http://ar.iiarjournals.org/content/40/5/2687.abstract N2 - Background/Aim: Transforming growth factor-β (TGF-β) plays dual suppressive and oncogenic roles in mammary carcinogenesis. Materials and Methods: To analyze whether TGF-β exerts suppressive or oncogenic actions on mammary carcinogenesis, transgenic mice overexpressing a dominant-negative mutant type II TGF-β receptor (TβRII-DNR) driven by the mouse mammary tumor virus (MMTV) promoter were treated with a low dose of urethane, a carcinogen present in fermented food products and alcoholic beverages. Results: Lobular proliferative lesions, showing high β-casein expression, developed in the mammary glands of TβRII-DNR+/+ mice aged >61 weeks. Compared with wild-type mice, TβRII-DNR+/+ mice administered with urethane showed significant increases in dysplastic hyperplasias and adenocarcinomas of the mammary glands. Conclusion: The functional decline of TGF-β signaling in mammary glands led to a high susceptibility to urethane-induced mammary carcinogenesis. TGF-β signaling may act as a tumor suppressor during mammary tumor development. ER -