TY - JOUR T1 - Grape Stem Extracts From Three Native Greek Vine Varieties Exhibit Strong Antioxidant and Antimutagenic Properties JF - Anticancer Research JO - Anticancer Res SP - 2025 LP - 2032 DO - 10.21873/anticanres.14159 VL - 40 IS - 4 AU - ARISTIDIS S. VESKOUKIS AU - ELENI VASSI AU - KONSTANTINOS POULAS AU - MANOLIS KOKKINAKIS AU - EFTIHIA ASPRODINI AU - SERKOS HAROUTOUNIAN AU - DEMETRIOS KOURETAS Y1 - 2020/04/01 UR - http://ar.iiarjournals.org/content/40/4/2025.abstract N2 - Background/Aim: The winemaking procedure results in the generation of stems, a by-product that is harmful to the environment. Concomitantly, stems are rich in polyphenols and, hence, they are putatively beneficial for human health. Materials and Methods: In this study, the grape stem extracts derived from three native Greek vine varieties, namely Mavrodaphne, Muscat and Rhoditis were examined for their chemical composition and antioxidant and antimutagenic properties using a battery of in vitro biomarkers. Results: All extracts are rich in polyphenols. Moreover, they exhibit potent antioxidant and antimutagenic properties with the extract of Mavrodaphne being the strongest in reducing the DPPH• and O2−• radicals and the Fe3+ and in protecting plasmid DNA from peroxyl radical-induced oxidative modification. Conclusion: Therefore, although they are serious pollutants, grape stems contain phytochemicals with important biological properties and can be used as (ingredients of) bio-functional foods to improve certain aspects of human health. ER -