PT  - JOURNAL ARTICLE
AU  - AMALIA GONZALEZ
AU  - EVAN J. WALKER
AU  - KATHERINE VAN LOON
AU  - PELIN CINAR
AU  - CHLOE E. ATREYA
TI  - Postoperative Exacerbation of Oxaliplatin-induced Neurotoxicity in Gastrointestinal Cancers: A Case Series
AID  - 10.21873/anticanres.14019
DP  - 2020 Feb 01
TA  - Anticancer Research
PG  - 865--871
VI  - 40
IP  - 2
4099  - http://ar.iiarjournals.org/content/40/2/865.short
4100  - http://ar.iiarjournals.org/content/40/2/865.full
SO  - Anticancer Res2020 Feb 01; 40
AB  - Background/Aim: Oxaliplatin-induced neurotoxicity (OIN) can be severe and dose-limiting with clinically significant symptoms that persist for years. Few published reports have described postoperative exacerbation of OIN and more longitudinal data are needed to better characterize the phenomenon. Patients and Methods: We identified 13 patients diagnosed with colon (n=7), rectal (n=4) or pancreatic (n=2) cancer who experienced postoperative OIN exacerbation at our medical center. Charts were reviewed for demographic and clinical data regarding OIN. Results: OIN exacerbation was documented 0.5-7.0 months after the first surgery following oxaliplatin exposure, with a median duration of 10.6 months (range=1.4-86.1 months). OIN exacerbation persisted in 3/13 patients at last follow-up, and improved to pre-operative levels in 6/13 patients (with complete resolution in 4/13) within a median of 3.6 months from initial exacerbation. Conclusion: Given the widespread use of oxaliplatin in neoadjuvant and first-line treatment for gastrointestinal cancers, further study is warranted to prospectively and systematically define risks for postoperative OIN exacerbation.