PT  - JOURNAL ARTICLE
AU  - HYUN-SOO KIM
AU  - SUNG-IM DO
AU  - DONG-HOON KIM
AU  - SOPHIA APPLE
TI  - Clinicopathological and Prognostic Significance of Programmed Death Ligand 1 Expression in Korean Patients With Triple-negative Breast Carcinoma
AID  - 10.21873/anticanres.14093
DP  - 2020 Mar 01
TA  - Anticancer Research
PG  - 1487--1494
VI  - 40
IP  - 3
4099  - http://ar.iiarjournals.org/content/40/3/1487.short
4100  - http://ar.iiarjournals.org/content/40/3/1487.full
SO  - Anticancer Res2020 Mar 01; 40
AB  - Background/Aim: The clinicopathological and prognostic significances of programmed death ligand 1 (PD-L1) expression in triple-negative breast carcinoma (TNBC) are still unclear. We investigated whether PD-L1 expression is associated with clinicopathological characteristics and outcomes of TNBC patients. Materials and Methods: We performed immunostaining for PD-L1 (SP142) in 83 TNBCs. Staining proportion of ≥1% was regarded as positive PD-L1 expression. Results: Positive intratumoral (IT) PD-L1 expression (19/83; 22.9%) was inversely associated with lymphovascular invasion (LVI) and distant metastasis, and was significantly associated with better disease-free survival for TNBC patients. Positive stromal PD-L1 expression (44/83; 53.0%) also correlated inversely with LVI. Conclusion: Positive IT PD-L1 expression was associated with favorable outcomes in TNBC. In addition, positive IT and stromal PD-L1 were inversely associated with LVI and distant metastasis of TNBC.