TY - JOUR T1 - The Significant Association of <em>MMP-1</em> Genotypes With Taiwan Pterygium JF - Anticancer Research JO - Anticancer Res SP - 703 LP - 707 DO - 10.21873/anticanres.14000 VL - 40 IS - 2 AU - CHONG-BIN TSAI AU - NING-YI HSIA AU - YUN-CHI WANG AU - ZHI-HONG WANG AU - YU-TING CHIN AU - TAI-LIN HUANG AU - CHIEN-CHIH YU AU - WEN-SHIN CHANG AU - CHIA-WEN TSAI AU - MEI-CHIN YIN AU - DA-TIAN BAU Y1 - 2020/02/01 UR - http://ar.iiarjournals.org/content/40/2/703.abstract N2 - Background/Aim: Few studies have examined the contribution of matrix metalloproteinases (MMP) to either diagnosis or prognosis of pterygium. The aim of this study was to investigate the contribution of MMP-1 genotypes to pterygium risk. Patients and Methods: A total of 134 cases and 268 controls were included and their MMP-1 -1607 (rs1799705) genotypes were examined by polymerase chain reaction-restriction fragment length polymorphism. Results: The percentages of 2G/2G, 1G/2G, and 1G/1G for rs1799705 genotypes were 48.5, 36.6 and 14.9% among patients and 33.9, 44.8, and 21.3% among controls (p trend=0.0167). The odds ratios (ORs) after adjusting for age and gender for 1G/2G and 1G/1G genotypes at rs1799705 were 0.54 (95%CI=0.33-0.89, p=0.0168) and 0.46 (95%CI=0.27-0.88, p=0.0192), respectively. Consistently, the adjusted OR for those carrying the 1G allele at MMP-1 -1607 was 0.61 (95%CI=0.41-0.78, p=0.0167), compared with the wild-type 2G allele. Conclusion: The genotypes at rs1799705 play a role in determining personal susceptibility to pterygium. ER -