PT  - JOURNAL ARTICLE
AU  - TSAI, CHONG-BIN
AU  - HSIA, NING-YI
AU  - WANG, YUN-CHI
AU  - WANG, ZHI-HONG
AU  - CHIN, YU-TING
AU  - HUANG, TAI-LIN
AU  - YU, CHIEN-CHIH
AU  - CHANG, WEN-SHIN
AU  - TSAI, CHIA-WEN
AU  - YIN, MEI-CHIN
AU  - BAU, DA-TIAN
TI  - The Significant Association of <em>MMP-1</em> Genotypes With Taiwan Pterygium
AID  - 10.21873/anticanres.14000
DP  - 2020 Feb 01
TA  - Anticancer Research
PG  - 703--707
VI  - 40
IP  - 2
4099  - http://ar.iiarjournals.org/content/40/2/703.short
4100  - http://ar.iiarjournals.org/content/40/2/703.full
SO  - Anticancer Res2020 Feb 01; 40
AB  - Background/Aim: Few studies have examined the contribution of matrix metalloproteinases (MMP) to either diagnosis or prognosis of pterygium. The aim of this study was to investigate the contribution of MMP-1 genotypes to pterygium risk. Patients and Methods: A total of 134 cases and 268 controls were included and their MMP-1 -1607 (rs1799705) genotypes were examined by polymerase chain reaction-restriction fragment length polymorphism. Results: The percentages of 2G/2G, 1G/2G, and 1G/1G for rs1799705 genotypes were 48.5, 36.6 and 14.9% among patients and 33.9, 44.8, and 21.3% among controls (p trend=0.0167). The odds ratios (ORs) after adjusting for age and gender for 1G/2G and 1G/1G genotypes at rs1799705 were 0.54 (95%CI=0.33-0.89, p=0.0168) and 0.46 (95%CI=0.27-0.88, p=0.0192), respectively. Consistently, the adjusted OR for those carrying the 1G allele at MMP-1 -1607 was 0.61 (95%CI=0.41-0.78, p=0.0167), compared with the wild-type 2G allele. Conclusion: The genotypes at rs1799705 play a role in determining personal susceptibility to pterygium.