RT Journal Article SR Electronic T1 Assessment of Factors Predicting Disease Progression in Japanese Patients With Non-Metastatic Castration-resistant Prostate Cancer JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 1101 OP 1106 DO 10.21873/anticanres.14049 VO 40 IS 2 A1 HIDEAKI MIYAKE A1 KYOHEI WATANABE A1 YUTO MATSUSHITA A1 HIROMITSU WATANABE A1 KEITA TAMURA A1 DAISUKE MOTOYAMA A1 TOSHIKI ITO A1 TAKAYUKI SUGIYAMA A1 ATSUSHI OTSUKA YR 2020 UL http://ar.iiarjournals.org/content/40/2/1101.abstract AB Background/Aim: Despite recent introduction of several novel agents, limited data exist regarding parameters that help predict the progression of non-metastatic castration-resistant prostate cancer (nmCRPC). The objective of this study was to identify prognostic predictors in nmCRPC patients. Patients and Methods: This study included 127 consecutive Japanese nmCRPC patients treated in routine clinical practice. Prognostic outcomes in these patients were analyzed to evaluate the impact of several parameters on prostate-specific antigen progression-free survival (PSA PFS) and metastasis-free survival (MFS). Results: When the 127 patients were diagnosed with nmCRPC, the PSA and PSA doubling time (PSADT) were 13.5 ng/ml and 17.9 months, respectively. Of these, 77 (60.6%) and 50 (39.4%) were treated with first-generation anti-androgen (FGA) and novel androgen-receptor-axis-targeted agent (ARATA), respectively, as first-line therapy for nmCRPC. The median PSA PFS and MFS after the diagnosis of nmCRPC in these patients were 29.5 months and not reached, respectively. Multivariate analyses identified the following independent prognostic factors: PSA at nmCRPC, PSADT and first-line therapy for nmCRPC for PSA PFS, and PSA at nmCRPC and PSADT for MFS. Conclusion: nmCRPC patients with higher PSA and/or shorter PSADT should be treated with ARATA rather than FGA.