RT Journal Article
SR Electronic
T1 Association of <em>Adiponectin</em> Genotypes With Colorectal Cancer Susceptibility in Taiwan
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 1297
OP 1306
DO 10.21873/anticanres.14071
VO 40
IS 3
A1 YI-CHIH HUNG
A1 WEN-SHIN CHANG
A1 AN-KUO CHOU
A1 JEN-SHENG PEI
A1 MEI-DUE YANG
A1 HORNG-REN YANG
A1 TA-MING YANG
A1 YUN-CHI WANG
A1 YU-CHEN HSIAU
A1 CHOU-PIN CHEN
A1 CHOU-CHEN CHEN
A1 CHIEN-CHIH YU
A1 CHIA-WEN TSAI
A1 DA-TIAN BAU
YR 2020
UL http://ar.iiarjournals.org/content/40/3/1297.abstract
AB Aim: To investigate the association between adiponectin (ADIPOQ) genotypes and colorectal cancer (CRC) risk among Taiwanese. Materials and Methods: Polymerase chain reaction–restriction fragment length polymorphism was adopted to identify ADIPOQ rs266729, rs2241766 and rs1501299 genotypes among 362 CRC patients and 362 healthy controls. Results: ADIPOQ rs266729 GG genotype (p=0.0075) and G allele (p=0.0061) are associated with a significantly increased CRC risk. There is no differential distribution of rs2241766 and rs1501299 genotypes. As for the gene–lifestyle interaction, there are obvious joint effects of rs266729 genotype on the CRC risk among non-smoker, non-alcohol drinker, while not on smoker or non-drinker subgroups. No significant correlation was observed between rs266729 genotypic distributions and age, gender, tumor size, location or metastasis status. Interestingly, a correlation of rs266729 genotype and larger BMI on CRC risk was found. Conclusion: G allele at ADIPOQ rs266729 may serve as a determiner for CRC risk, especially for those with BMI ≥24.