RT Journal Article SR Electronic T1 Association of Adiponectin Genotypes With Colorectal Cancer Susceptibility in Taiwan JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 1297 OP 1306 DO 10.21873/anticanres.14071 VO 40 IS 3 A1 HUNG, YI-CHIH A1 CHANG, WEN-SHIN A1 CHOU, AN-KUO A1 PEI, JEN-SHENG A1 YANG, MEI-DUE A1 YANG, HORNG-REN A1 YANG, TA-MING A1 WANG, YUN-CHI A1 HSIAU, YU-CHEN A1 CHEN, CHOU-PIN A1 CHEN, CHOU-CHEN A1 YU, CHIEN-CHIH A1 TSAI, CHIA-WEN A1 BAU, DA-TIAN YR 2020 UL http://ar.iiarjournals.org/content/40/3/1297.abstract AB Aim: To investigate the association between adiponectin (ADIPOQ) genotypes and colorectal cancer (CRC) risk among Taiwanese. Materials and Methods: Polymerase chain reaction–restriction fragment length polymorphism was adopted to identify ADIPOQ rs266729, rs2241766 and rs1501299 genotypes among 362 CRC patients and 362 healthy controls. Results: ADIPOQ rs266729 GG genotype (p=0.0075) and G allele (p=0.0061) are associated with a significantly increased CRC risk. There is no differential distribution of rs2241766 and rs1501299 genotypes. As for the gene–lifestyle interaction, there are obvious joint effects of rs266729 genotype on the CRC risk among non-smoker, non-alcohol drinker, while not on smoker or non-drinker subgroups. No significant correlation was observed between rs266729 genotypic distributions and age, gender, tumor size, location or metastasis status. Interestingly, a correlation of rs266729 genotype and larger BMI on CRC risk was found. Conclusion: G allele at ADIPOQ rs266729 may serve as a determiner for CRC risk, especially for those with BMI ≥24.