PT  - JOURNAL ARTICLE
AU  - HUNG, YI-CHIH
AU  - CHANG, WEN-SHIN
AU  - CHOU, AN-KUO
AU  - PEI, JEN-SHENG
AU  - YANG, MEI-DUE
AU  - YANG, HORNG-REN
AU  - YANG, TA-MING
AU  - WANG, YUN-CHI
AU  - HSIAU, YU-CHEN
AU  - CHEN, CHOU-PIN
AU  - CHEN, CHOU-CHEN
AU  - YU, CHIEN-CHIH
AU  - TSAI, CHIA-WEN
AU  - BAU, DA-TIAN
TI  - Association of <em>Adiponectin</em> Genotypes With Colorectal Cancer Susceptibility in Taiwan
AID  - 10.21873/anticanres.14071
DP  - 2020 Mar 01
TA  - Anticancer Research
PG  - 1297--1306
VI  - 40
IP  - 3
4099  - http://ar.iiarjournals.org/content/40/3/1297.short
4100  - http://ar.iiarjournals.org/content/40/3/1297.full
SO  - Anticancer Res2020 Mar 01; 40
AB  - Aim: To investigate the association between adiponectin (ADIPOQ) genotypes and colorectal cancer (CRC) risk among Taiwanese. Materials and Methods: Polymerase chain reaction–restriction fragment length polymorphism was adopted to identify ADIPOQ rs266729, rs2241766 and rs1501299 genotypes among 362 CRC patients and 362 healthy controls. Results: ADIPOQ rs266729 GG genotype (p=0.0075) and G allele (p=0.0061) are associated with a significantly increased CRC risk. There is no differential distribution of rs2241766 and rs1501299 genotypes. As for the gene–lifestyle interaction, there are obvious joint effects of rs266729 genotype on the CRC risk among non-smoker, non-alcohol drinker, while not on smoker or non-drinker subgroups. No significant correlation was observed between rs266729 genotypic distributions and age, gender, tumor size, location or metastasis status. Interestingly, a correlation of rs266729 genotype and larger BMI on CRC risk was found. Conclusion: G allele at ADIPOQ rs266729 may serve as a determiner for CRC risk, especially for those with BMI ≥24.