TY - JOUR T1 - Association of <em>Adiponectin</em> Genotypes With Colorectal Cancer Susceptibility in Taiwan JF - Anticancer Research JO - Anticancer Res SP - 1297 LP - 1306 DO - 10.21873/anticanres.14071 VL - 40 IS - 3 AU - YI-CHIH HUNG AU - WEN-SHIN CHANG AU - AN-KUO CHOU AU - JEN-SHENG PEI AU - MEI-DUE YANG AU - HORNG-REN YANG AU - TA-MING YANG AU - YUN-CHI WANG AU - YU-CHEN HSIAU AU - CHOU-PIN CHEN AU - CHOU-CHEN CHEN AU - CHIEN-CHIH YU AU - CHIA-WEN TSAI AU - DA-TIAN BAU Y1 - 2020/03/01 UR - http://ar.iiarjournals.org/content/40/3/1297.abstract N2 - Aim: To investigate the association between adiponectin (ADIPOQ) genotypes and colorectal cancer (CRC) risk among Taiwanese. Materials and Methods: Polymerase chain reaction–restriction fragment length polymorphism was adopted to identify ADIPOQ rs266729, rs2241766 and rs1501299 genotypes among 362 CRC patients and 362 healthy controls. Results: ADIPOQ rs266729 GG genotype (p=0.0075) and G allele (p=0.0061) are associated with a significantly increased CRC risk. There is no differential distribution of rs2241766 and rs1501299 genotypes. As for the gene–lifestyle interaction, there are obvious joint effects of rs266729 genotype on the CRC risk among non-smoker, non-alcohol drinker, while not on smoker or non-drinker subgroups. No significant correlation was observed between rs266729 genotypic distributions and age, gender, tumor size, location or metastasis status. Interestingly, a correlation of rs266729 genotype and larger BMI on CRC risk was found. Conclusion: G allele at ADIPOQ rs266729 may serve as a determiner for CRC risk, especially for those with BMI ≥24. ER -