TY - JOUR T1 - The Association of <em>MMP7</em> Promoter Polymorphisms With Gastric Cancer JF - Anticancer Research JO - Anticancer Res SP - 695 LP - 702 DO - 10.21873/anticanres.13999 VL - 40 IS - 2 AU - CHUN-KAI FU AU - YI-CHUN CHIEN AU - HUI-YEN CHUANG AU - YUN-CHI WANG AU - JENG-JONG HWANG AU - MEI-DUE YANG AU - CHIEN-CHIH YU AU - JAW-CHYUN CHEN AU - WEN-SHIN CHANG AU - DA-TIAN BAU AU - CHIA-WEN TSAI Y1 - 2020/02/01 UR - http://ar.iiarjournals.org/content/40/2/695.abstract N2 - Background/Aim: Few studies have examined the genetic role of matrix metalloproteinases (MMPs) to early detection or prediction in gastric cancer development. In this study, the contribution of MMP7 promoter (A-181G and C-153T) polymorphic genotypes to gastric cancer risk in Taiwanese was investigated for the first time. Materials and Methods: A total of 121 cases and 363 controls were enrolled and their MMP7 genotypes at A-181G and C-153T were examined by polymerase chain reaction-restriction fragment length polymorphism methodology using genomic DNA from serum. Results: The GG genotype at MMP7 A-181G was found to represent a risk factor for gastric cancer, especially among smokers. No individual with variant genotype carrier at MMP7 C-153T was found among this Taiwanese population. Conclusion: The G allele of MMP7 A-181G may serve as an early predictor for gastric cancer risk in Taiwanese; other gastric cancer markers are still urgently needed. ER -