%0 Journal Article %A CHUN-KAI FU %A YI-CHUN CHIEN %A HUI-YEN CHUANG %A YUN-CHI WANG %A JENG-JONG HWANG %A MEI-DUE YANG %A CHIEN-CHIH YU %A JAW-CHYUN CHEN %A WEN-SHIN CHANG %A DA-TIAN BAU %A CHIA-WEN TSAI %T The Association of MMP7 Promoter Polymorphisms With Gastric Cancer %D 2020 %R 10.21873/anticanres.13999 %J Anticancer Research %P 695-702 %V 40 %N 2 %X Background/Aim: Few studies have examined the genetic role of matrix metalloproteinases (MMPs) to early detection or prediction in gastric cancer development. In this study, the contribution of MMP7 promoter (A-181G and C-153T) polymorphic genotypes to gastric cancer risk in Taiwanese was investigated for the first time. Materials and Methods: A total of 121 cases and 363 controls were enrolled and their MMP7 genotypes at A-181G and C-153T were examined by polymerase chain reaction-restriction fragment length polymorphism methodology using genomic DNA from serum. Results: The GG genotype at MMP7 A-181G was found to represent a risk factor for gastric cancer, especially among smokers. No individual with variant genotype carrier at MMP7 C-153T was found among this Taiwanese population. Conclusion: The G allele of MMP7 A-181G may serve as an early predictor for gastric cancer risk in Taiwanese; other gastric cancer markers are still urgently needed. %U https://ar.iiarjournals.org/content/anticanres/40/2/695.full.pdf