@article {FU695, author = {CHUN-KAI FU and YI-CHUN CHIEN and HUI-YEN CHUANG and YUN-CHI WANG and JENG-JONG HWANG and MEI-DUE YANG and CHIEN-CHIH YU and JAW-CHYUN CHEN and WEN-SHIN CHANG and DA-TIAN BAU and CHIA-WEN TSAI}, title = {The Association of MMP7 Promoter Polymorphisms With Gastric Cancer}, volume = {40}, number = {2}, pages = {695--702}, year = {2020}, doi = {10.21873/anticanres.13999}, publisher = {International Institute of Anticancer Research}, abstract = {Background/Aim: Few studies have examined the genetic role of matrix metalloproteinases (MMPs) to early detection or prediction in gastric cancer development. In this study, the contribution of MMP7 promoter (A-181G and C-153T) polymorphic genotypes to gastric cancer risk in Taiwanese was investigated for the first time. Materials and Methods: A total of 121 cases and 363 controls were enrolled and their MMP7 genotypes at A-181G and C-153T were examined by polymerase chain reaction-restriction fragment length polymorphism methodology using genomic DNA from serum. Results: The GG genotype at MMP7 A-181G was found to represent a risk factor for gastric cancer, especially among smokers. No individual with variant genotype carrier at MMP7 C-153T was found among this Taiwanese population. Conclusion: The G allele of MMP7 A-181G may serve as an early predictor for gastric cancer risk in Taiwanese; other gastric cancer markers are still urgently needed.}, issn = {0250-7005}, URL = {https://ar.iiarjournals.org/content/40/2/695}, eprint = {https://ar.iiarjournals.org/content/40/2/695.full.pdf}, journal = {Anticancer Research} }