TY - JOUR T1 - Chondrosarcoma of the Chest Wall: A Review of 53 Cases from Two Institutions JF - Anticancer Research JO - Anticancer Res SP - 1519 LP - 1526 DO - 10.21873/anticanres.14097 VL - 40 IS - 3 AU - ULRICH LENZE AU - ANDREA ANGELINI AU - FLORIAN POHLIG AU - CAROLIN KNEBEL AU - GIULIA TROVARELLI AU - ANTONIO BERIZZI AU - ANDREAS F. MAVROGENIS AU - JOERG THEISEN AU - RUEDIGER VON EISENHART-ROTHE AU - PIETRO RUGGIERI Y1 - 2020/03/01 UR - http://ar.iiarjournals.org/content/40/3/1519.abstract N2 - Background/Aim: Chondrosarcomas (CS) of the chest wall are rare, but present an aggressive biological behavior compared to CS of the extremities. The aims of the present study were to determine factors associated with oncological outcomes as well as complications. Patients and Methods: We retrospectively analyzed 53 patients (42 primary, 11 recurrent tumors). In total, 39 central CS, 10 peripheral CS, 3 dedifferentiated CS and 1 mesenchymal CS were included. The ribs were most commonly affected (68%). Overall survival and disease-free survival were estimated with Kaplan-Meier analyses and compared with log-rank test. Results: Mean follow-up was 7 years. Negative margins were achieved in 87% of patients. Thirty patients (57%) remained continuously disease-free (NED), three (5%) NED after treatment of relapse, seven (13%) were alive with disease, twelve (23%) were dead with disease and one of other cause. The 10-year survival rate was 81% and 45% in primary and recurrent tumors, respectively. Survival was significantly affected by tumor stage (p<0.001), local recurrence (p=0.025) and metastases (p=0.002). Six complications (16%) were observed. Conclusion: The outcome is rather poor, especially in patients with local recurrence. Presumably due to a high biological aggressiveness, a stricter definition of surgical margins should be considered for this location. ER -