RT Journal Article SR Electronic T1 Immunoglobulin Restores Immune Responses to BTH1677 in Patients With Low Levels of Antibodies to Beta-glucan JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 1467 OP 1473 DO 10.21873/anticanres.14090 VO 40 IS 3 A1 HURLEY, PETER J. A1 BOSE, NANDITA A1 JHA, GAUTAM A1 GARGANO, MICHELE A1 OTTOSON, NADINE A1 GORDEN, KEITH A1 RATHMANN, BLAINE A1 HARRISON, BEN A1 QIU, XIAOHONG A1 DUDEK, ARKADIUSZ Z. YR 2020 UL http://ar.iiarjournals.org/content/40/3/1467.abstract AB Background: BTH1677 is a beta-glucan pathogen-associated molecular pattern (PAMP) being evaluated as a novel immunotherapy of cancer. We previously described that the presence of antibodies against beta-glucan (ABA) in serum is necessary for BTH1677 antitumoral activity. We hypothesized that infusion of immunoglobulin can reinstate responses to BTH1677 in individuals with low ABA levels. Patients and Methods: We report two single-patient studies: one in a patient with metastatic colorectal cancer who received BTH1677, combined with tumor targeting antibody cetuximab; and a second in a patient with metastatic neuroendocrine tumor who received BTH1677 combined with immune checkpoint inhibitor pembrolizumab. Results: The patients had low serum titers of ABA and low innate immune effector functionality induced by BTH1677. Addition of intravenous immunoglobulins restored innate immune activity of BTH1677 and induced clinically meaningful anti-tumoral activity, with long-term disease control. Conclusion: Infusion of immunoglobulin can restore activity of BTH1677 in individuals with low serum ABA level.