RT Journal Article SR Electronic T1 Risk Factors of Severe Benign Cicatricial Stricture After Definitive Chemoradiation for Localized T3 Esophageal Carcinoma JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 1071 OP 1077 DO 10.21873/anticanres.14045 VO 40 IS 2 A1 NATSUKO SATOMI-TSUSHITA A1 YOSHITAKA HONMA A1 KENGO NAGASHIMA A1 YOSHINORI ITO A1 HIDEKAZU HIRANO A1 HIROKAZU SHOJI A1 ATSUO TAKASHIMA A1 SATORU IWASA A1 KEN KATO A1 TETSUYA HAMAGUCHI A1 JUN ITAMI A1 NARIKAZU BOKU YR 2020 UL http://ar.iiarjournals.org/content/40/2/1071.abstract AB Background/Aim: Severe benign cicatricial stricture (SBCS) is a major complication after definitive chemoradiation therapy (dCRT) for esophageal squamous cell carcinoma (ESCC). This study was conducted to investigate risk factors of SBCS in patients with localized ESCC. Patients and Methods: This study included 197 patients with clinical stage (cSt) II/III ESCC with T3 primary tumor, treated with dCRT between 2000 and 2011. SBCS was defined as the inability to pass a 9-mm diameter endoscope or the presence of symptoms requiring treatment. Results: Complete response was obtained in 87 patients (44%). Multivariate analysis revealed that hypoalbuminemia (hazard ratio=5.65; 95% confidence interval=1.50-21.28; p=0.010) and the inability to pass an endoscope (hazard ratio=5.90; 95% confidence interval=1.52-22.85; p=0.010) were risk factors of SBCS. Conclusion: The inability to pass an endoscope and hypoalbuminemia were identified as risk factors of SBCS in patients with cSt II/III ESCC with T3 primary tumor.