%0 Journal Article %A DANIELA PIERSCIANEK %A YAHYA AHMADIPOUR %A ANNA MICHEL %A MEHDI CHIHI %A MARVIN DARKWAH OPPONG %A SIED KEBIR %A MARTIN GLAS %A MARTIN STUSCHKE %A ULRICH SURE %A RAMAZAN JABBARLI %T Preoperative Survival Prediction in Patients With Glioblastoma by Routine Inflammatory Laboratory Parameters %D 2020 %R 10.21873/anticanres.14058 %J Anticancer Research %P 1161-1166 %V 40 %N 2 %X Background: Glioblastoma (GBM) is the most common malignant brain tumor in adults and still carries a dismal prognosis. As several studies detected a connection between inflammation and GBM prognosis, we sought to explore possible associations between routinely investigated inflammatory parameters and GBM outcome. Patients and Methods: Patients treated for GBM at our Institution between 2004 and 2014 were included. White blood cell count (WBC), C-reactive protein (CRP) and the ratio of platelets and WBC (Plt/WBC) were evaluated preoperatively. Medical records were reviewed for clinical parameters (age, sex, preoperative clinical condition, genetic alterations). Study endpoints were overall (OS) and 1- and 2-year survival. Results: In the final cohort consisting of 565 individuals with GBM, univariate analysis showed significant associations for WBC, CRP and Plt/WBC ratio with OS. Kaplan–Meier survival plot confirmed significantly poorer OS in patients with WBC>12/nl and with CRP≥2.9 mg/dl. In multivariate analysis, a WBC of >12/nl was an independent prognostic factor for all three outcome parameters and CRP≥2.9 mg/dl for OS and 1-year survival. Conclusion: Preoperative WBC and CRP values were confirmed as independent predictors of GBM outcome. This emphasizes the need for further evaluation of the role of inflammation in the prognosis of GBM. %U https://ar.iiarjournals.org/content/anticanres/40/2/1161.full.pdf