TY - JOUR T1 - Prognosis of <em>EGFR</em>-mutant Lung Adenocarcinoma Patients With Malignant Pleural Effusion Receiving First-line EGFR-TKI Therapy Without Pleurodesis: A Single-institute Retrospective Study JF - Anticancer Research JO - Anticancer Res SP - 1117 LP - 1121 DO - 10.21873/anticanres.14051 VL - 40 IS - 2 AU - KOSUKE KASHIWABARA AU - SHINJI FUJI AU - SHINSUKE TSUMURA AU - KAZUHIKO SAKAMOTO Y1 - 2020/02/01 UR - http://ar.iiarjournals.org/content/40/2/1117.abstract N2 - Background/Aim: The survival benefit of first-line epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) therapy without pleurodesis in EGFR-mutant lung adenocarcinoma patients with malignant pleural effusions (MPE) remains unclear. Patients and Methods: We retrospectively evaluated overall survival (OS) among EGFR wild-type lung adenocarcinoma patients with MPE who received chemotherapy with pleurodesis (CT+PLD) and without pleurodesis (CT-PLD), and EGFR-mutant lung adenocarcinoma patients with MPE who received EGFR-TKI therapy with pleurodesis (TKI+PLD) and without pleurodesis (TKI-PLD). Results: There was no difference in OS between the CT+PLD and the CT-PLD groups (10.8 months vs. 7.4 months). As compared to the TKI+PLD group, OS tended to be longer in the TKI-PLD group (21.8 months vs. 31.1 months). Patients in the TKI-PLD group had no hypoalbuminemia or deterioration of performance status during management of MPE and could receive second- and further-line therapy. Conclusion: EGFR-mutant patients with MPE who received first-line EGFR-TKI therapy without pleurodesis may show a better prognosis than those with pleurodesis. ER -