PT  - JOURNAL ARTICLE
AU  - LINA ADOMAITIENE
AU  - RUTA NADISAUSKIENE
AU  - MAHSHID NICKKHO-AMIRY
AU  - ARVYDAS CIZAUSKAS
AU  - JOLITA PALUBINSKIENE
AU  - CATHRINE HOLLAND
AU  - MOURAD W. SEIF
TI  - Tumor Suppression in Asymptomatic Postmenopausal Endometrial Polyps
AID  - 10.21873/anticanres.14010
DP  - 2020 Feb 01
TA  - Anticancer Research
PG  - 789--794
VI  - 40
IP  - 2
4099  - http://ar.iiarjournals.org/content/40/2/789.short
4100  - http://ar.iiarjournals.org/content/40/2/789.full
SO  - Anticancer Res2020 Feb 01; 40
AB  - Background/Aim: To investigate tumor suppression as an indicator of malignization potential within endometrial polyps in asymptomatic postmenopausal women. Materials and Methods: Immunohistochemical studies of the phosphatase and tensin homolog (PTEN) were performed. Cases included 52 benign postmenopausal polyps, 19 endometrioid carcinomas with coexisting benign polyps, and 12 polyps with foci of carcinoma. Controls included 31 atrophic endometria and 32 benign premenopausal polyps. PTEN was scored by quantitative methods according to staining intensity. Results: The mean epithelial and stromal PTEN H-score in postmenopausal benign endometrial polyps (193.8 and 123.2, respectively) was significantly higher than that in the atrophic endometrium (135.5 and 90.2, p=0.008), and premenopausal benign endometrial polyps (100.7 and 198.7, p<0.001). Significant difference between postmenopausal endometrial polyps and endometrial carcinoma was noticed in the epithelial compartment (193.8 vs. 65.7, respectively, p<0.001). Conclusion: Asymptomatic benign postmenopausal polyps have a distinctively high tumor suppression compared with endometrial cancer, suggesting low malignization potential.