PT  - JOURNAL ARTICLE
AU  - YUKIKO NAKAMURA
AU  - KAZUHITO MIYAZAKI
AU  - NAOTO AIKO
AU  - YUKI MISUMI
AU  - YOKO AGEMI
AU  - YURI TANIGUCHI
AU  - MARI ISHI
AU  - TSUNEO SHIMOKAWA
AU  - HIROAKI OKAMOTO
AU  - TAKEHARU YAMANAKA
TI  - Efficacy of PD-1 Inhibitors in Older Non-small Cell Lung Cancer Patients
AID  - 10.21873/anticanres.14025
DP  - 2020 Feb 01
TA  - Anticancer Research
PG  - 923--928
VI  - 40
IP  - 2
4099  - http://ar.iiarjournals.org/content/40/2/923.short
4100  - http://ar.iiarjournals.org/content/40/2/923.full
SO  - Anticancer Res2020 Feb 01; 40
AB  - Background/Aim: We assessed the efficacy of immune checkpoint inhibitors (ICIs) in older patients because of the limited information regarding these patients. Patients and Methods: We retrospectively analyzed 66 consecutive patients ≥70 years old with advanced non-small cell lung cancer (NSCLC). A total of 31 patients received ICIs (ICIs group) and 35 patients received only cytotoxic regimens (No ICIs group). Results: Patients with squamous cell carcinoma who received ICIs had better overall survival (OS) than those who did not (9.7 versus 4.7 months, p=0.027). In multivariate analysis, treatment with ICIs [hazard ratio (HR)=0.54, 95% confidence interval (CI)=0.30-0.98, p=0.044], good performance status (HR=0.30, 95%CI=0.16-0.57, p=0.0003), and histology other than squamous cell carcinoma (HR=0.41, 95%CI=0.19-0.83, p=0.014) were significantly favorable factors for OS. Conclusion: ICIs may be effective for older patients with NSCLC, especially squamous cell carcinoma patients.