RT Journal Article
SR Electronic
T1 Topoisomerase IIa Protein Expression Patterns in Laryngeal Squamous Cell Carcinoma
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 807
OP 811
DO 10.21873/anticanres.14012
VO 40
IS 2
A1 VASILEIOS PAPANIKOLAOU
A1 ARISTEIDIS CHRYSOVERGIS
A1 NICHOLAS MASTRONIKOLIS
A1 EVANGELOS TSIAMBAS
A1 VASILEIOS RAGOS
A1 DIMITRIOS PESCHOS
A1 CHARA STAVRAKA
A1 DIMITRIOS ROUKAS
A1 EFTHYMIOS KYRODIMOS
YR 2020
UL http://ar.iiarjournals.org/content/40/2/807.abstract
AB Background/Aim: Topoisomerase II alpha (TopoIIa) is a critical gene associated with response to chemo-therapeutic agents, such as anthracyclines, especially in breast adenocarcinoma. The aim of this study was to investigate the role of aberrant TopoIIa protein expression in laryngeal squamous cell carcinoma (LSCC). Materials and Methods: Fifty (n=50) LSCC cases were enrolled in the study. Immunohistochemistry and a digital image analysis assay were implemented. Results: TopoIIa protein overexpression was observed in 32/50 (64%) cases, whereas low expression rates were detected in 18/50 (36%). TopoIIa overall expression presented strong association with the grade of the examined malignant tissues and borderline association with stage. TopoIIa overexpression correlated also with Human papillomavirus (HPV) positivity. Conclusion: TopoIIa overexpression was observed in significant subsets of LSCCs, and correlated predominantly with the grade of differentiation. HPV persistent infection seems to be associated with increased TopoIIa protein expression. TopoIIa expression analysis appears to be critical in identifying sub-groups of patients eligible for specific chemotherapy.