RT Journal Article
SR Electronic
T1 Prognostic Significance of ZKSCAN3 (ZNF306) Expression in Gastric Carcinoma
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 81
OP 86
DO 10.21873/anticanres.13928
VO 40
IS 1
A1 YUTA TAKANO
A1 ATSUO SHIDA
A1 MUNEHARU FUJISAKI
A1 NORIO MITSUMORI
A1 KATSUHIKO YANAGA
YR 2020
UL http://ar.iiarjournals.org/content/40/1/81.abstract
AB Background/Aim: Zinc finger protein ZKSCAN3 (ZNF306) is a promising oncogene candidate in colon, bladder, breast, uterine cervical, and prostate cancers. The present study aimed to investigate ZKSCAN3 protein expression in gastric carcinoma patient tissues and to evaluate oncological outcomes in these patients. Materials and Methods: ZKSCAN3 was detected using the anti-ZKSCAN3 rabbit polyclonal antibody. For immunohistochemical examination, we used paraffin-embedded specimens from 87 consecutive patients with gastric cancer who underwent gastrectomy. We investigated ZKSCAN3 expression in relation with patient prognosis and clinicopathological factors. Results: ZKSCAN3 was detected in 28 (32.2%) tumour specimens, with significant association with lymphatic system invasion and distant metastasis. Patients with ZKSCAN3-positive tumours had worse overall survival (OS) than those with ZKSCAN3-negative tumours based on log-rank testing. Furthermore, multivariate analysis revealed that ZKSCAN3 was an independent prognostic parameter for OS (hazard ratio: 2.6379, p=0.0164). Conclusion: ZKSCAN3 is a potential novel prognostic factor in gastric cancer patients.