PT  - JOURNAL ARTICLE
AU  - LARS KATTNER
TI  - Recent Developments Towards the Synthesis of Vitamin D Metabolites
AID  - 10.21873/anticanres.13980
DP  - 2020 Jan 01
TA  - Anticancer Research
PG  - 519--525
VI  - 40
IP  - 1
4099  - http://ar.iiarjournals.org/content/40/1/519.short
4100  - http://ar.iiarjournals.org/content/40/1/519.full
SO  - Anticancer Res2020 Jan 01; 40
AB  - Due to latest advancements in the development of LC-MS/MS based assays and their applications in clinical chemistry, low abundant vitamin D metabolites can be detected at low concentration with high specificity. Consequently, there is a growing need for their synthesis as stable isotopically labeled compounds to be used as calibration and reference standards. Most commonly, ex chiral pool synthesis, starting with vitamin D2, and palladium(0) catalyzed coupling reactions are applied in vitamin D synthesis. By contrast, little is known so far regarding the application of cobalt complexes for this purpose. In fact, the Pausen-Khand reaction can be applied for the synthesis of a wide range of isotopically labeled vitamin D metabolites that are hardly accessible by other known methods. Applications, scope and limitations of the most recent vitamin D synthesis methods, with a particular focus on this new promising methodology using Co-complexes, are discussed.