TY - JOUR T1 - Variable Genomic and Metabolomic Responses to Varying Doses of Vitamin D Supplementation JF - Anticancer Research JO - Anticancer Res SP - 535 LP - 543 DO - 10.21873/anticanres.13982 VL - 40 IS - 1 AU - ARASH SHIRVANI AU - TYLER AREK KALAJIAN AU - ANJELI SONG AU - RACHEL ALLEN AU - NIPITH CHAROENNGAM AU - RICHARD LEWANCZUK AU - MICHAEL F. HOLICK Y1 - 2020/01/01 UR - http://ar.iiarjournals.org/content/40/1/535.abstract N2 - Background/Aim: To assess the impact of vitamin D supplementation on genomic and metabolomic profiles and relate them to the individual's responsiveness to varying doses of vitamin D3. Patients and Methods: Healthy adults were given either 600, 4000 or 10,000 IUs vitamin D3/day for 6 months. Circulating parathyroid hormone (PTH), 25-hydroxyvitamin D [25(OH)D], calcium, peripheral white blood cells broad gene expression and urine and serum metabolomic profiles were evaluated. Results: There was a dose-dependent effect of vitamin D supplementation on serum 25(OH)D, PTH and broad gene expression. Serum calcium levels remained normal for all study subjects and no untoward toxicity was observed. The metabolomic profiles were related to the genomic expression analysis. There were significant inter-individual effects on gene expression and metabolomic profile in response to the same dose of vitamin D3 supplementation, despite similar changes in 25(OH)D and PTH concentrations. Conclusion: These results may help explain the variability observed in clinical trials regarding vitamin D's non-calcemic health benefits. ER -