RT Journal Article
SR Electronic
T1 Clinicopathological Features, Surgical Outcomes, Oncogenic Status and PD-L1 Expression of Pulmonary Pleomorphic Carcinoma
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 5789
OP 5795
DO 10.21873/anticanres.13782
VO 39
IS 10
A1 NAKANISHI, KEITA
A1 SAKAKURA, NORIAKI
A1 MATSUI, TAKUYA
A1 UENO, HARUSHI
A1 NAKADA, TAKEO
A1 OYA, YUKO
A1 SHIMIZU, JUNICHI
A1 HIDA, TOYOAKI
A1 HOSODA, WAKI
A1 KURODA, HIROAKI
YR 2019
UL http://ar.iiarjournals.org/content/39/10/5789.abstract
AB Background/Aim: Pulmonary pleomorphic carcinoma (PPC) is rare, and few studies have reported its features. We assessed the clinicopathological features, surgical outcomes, oncogenic status and programmed death-ligand 1 (PD-L1) expression of PPC. Patients and Methods: We retrospectively reviewed data from 22 consecutive patients who underwent resection of PPC between 2007 and 2017. Results: The predominant tissue type of the epithelial component was adenocarcinoma in 15 patients (68%) and the others in 7 patients (32%), and the 3-year disease-free survival rate tended to be better in patients with an adenocarcinoma component compared to patients with another component (40.0% vs. 17.1%, p=0.059). PD-L1 expression was observed in all eight tumors whose PD-L1 status could be examined and high PD-L1 expression (≥50%) was frequent (5/8, 63%). Conclusion: A predominant adenocarcinoma epithelial component in PPC might be associated with better survival outcomes and high PD-L1 expression might be frequent in PPC.