TY - JOUR T1 - Genetic Polymorphisms in IL-10 Promoter Are Associated With Smoking and Prostate Cancer Risk in African Americans JF - Anticancer Research JO - Anticancer Res SP - 27 LP - 34 DO - 10.21873/anticanres.13923 VL - 40 IS - 1 AU - MUNEER ABBAS AU - TSHELA MASON AU - ALIZA IBAD AU - MOZNA KHRAIWESH AU - VICTOR APPREY AU - YASMINE KANAAN AU - BRADFORD WILSON AU - GEORGIA DUNSTON AU - LUISEL RICKS-SANTI AU - HASSAN BRIM Y1 - 2020/01/01 UR - http://ar.iiarjournals.org/content/40/1/27.abstract N2 - Background/Aim: Even though prostate cancer (PCa) has good prognosis, there is a discrepancy in the risk among ethnic groups, with high morbidity in African American men. Single nucleotide polymorphisms (SNPs) in interleukin 10 (IL-10) have been associated with inflammation and cancer risk. We investigated the association of five SNPs in the IL-10 promoter with clinical features such as Gleason score and smoking. Materials and Methods: A total of 413 DNA samples were obtained from a nested case-control study of African American males who were genotyped for 5 SNPs utilizing pyrosequencing. Multiple and binary logistic regression models were applied to analyze the clinical and genotypic data. Results: rs12122923 and rs1800871 were associated with PCa risk. Smoking was also found to increase the risk of PCa by 1.6-fold. rs1800893 was found to be associated with lower grades for prostate cancer. Conclusion: IL-10 promoter polymorphisms might be a risk factor for PCa development in smoking subjects and PCa progression. ER -