TY - JOUR T1 - Pulmonary Oligometastases Treated by Stereotactic Body Radiation Therapy: A Nationwide Survey of 1,378 Patients JF - Anticancer Research JO - Anticancer Res SP - 393 LP - 399 DO - 10.21873/anticanres.13965 VL - 40 IS - 1 AU - YUZURU NIIBE AU - TAKAYA YAMAMOTO AU - HIROSHI ONISHI AU - HIDEOMI YAMASHITA AU - KUNIAKI KATSUI AU - YASUO MATSUMOTO AU - RYOONG-JIN OH AU - MASAHIKO AOKI AU - TAKASHI SHINTANI AU - KAZUNARI YAMADA AU - MITSURU KOBAYASHI AU - MASATOKI OZAKI AU - YOSHIHIKO MANABE AU - KATSUYA YAHARA AU - ATSUSHI NISHIKAWA AU - HISAO KAKUHARA AU - KENTARO YAMAMOTO AU - TETSUYA INOUE AU - YU TAKADA AU - KENJI NAGATA AU - OSAMU SUZUKI AU - ATSURO TERAHARA AU - KEIICHI JINGU Y1 - 2020/01/01 UR - http://ar.iiarjournals.org/content/40/1/393.abstract N2 - Aim: This study was performed to confirm the superior overall survival (OS) after pulmonary oligo-recurrence compared to pulmonary sync-oligometastases in a large nationwide study. Patients and Methods: Patients that met the following criteria were included: 1 to 5 lung-only metastases at the beginning of stereotactic body radiation therapy (SBRT) was performed between January 2004 and June 2015, and the biological effective dose (BED) of SBRT was 75 Gy or more. The parameters included in the analyses were age, gender, ECOG PS, primary lesion, pathology, oligoetastatic state, SBRT date, chemotherapy before SBRT, chemotherapy concurrent SBRT, chemotherapy after SBRT, maximum tumor diameter, number of metastases, field coplanarity, dose prescription, BED10, OTT of SBRT. Results: In total, 1,378 patients with 1,547 tumors were enrolled. Oligo-recurrence occurred in 1,016 patients, sync-oligometastases in 118, and unclassified oligometastases in 121. The three-year OS was 64.0% for oligo-recurrence and 47.5% for sync-oligometastasis (p<0.001). In the multivariate analysis, the hazard ratio (HR) for sync-oligometastases versus oligo-recurrence was 1.601 (p=0.014). Adverse events of Grade 5 were occurred in 3 patients. Conclusion: This is the first nationwide to indicate that the OS of patients with pulmonary oligo-recurrence is better than that of patients with sync-oligometastases. ER -