PT - JOURNAL ARTICLE AU - JÖRG REICHRATH AU - PELLE G. LINDQVIST AU - STEFAN PILZ AU - WINFRIED MÄRZ AU - WILLIAM B. GRANT AU - MICHAEL F. HOLICK AU - FRANK R. DE GRUIJL TI - Sunbeds and Melanoma Risk: Many Open Questions, Not Yet Time to Close the Debate AID - 10.21873/anticanres.13978 DP - 2020 Jan 01 TA - Anticancer Research PG - 501--509 VI - 40 IP - 1 4099 - http://ar.iiarjournals.org/content/40/1/501.short 4100 - http://ar.iiarjournals.org/content/40/1/501.full SO - Anticancer Res2020 Jan 01; 40 AB - Background: Intensive scientific debate is ongoing about whether moderate solarium use increases melanoma risk. The authors of some recent publications demand the debate be closed and propose “actions against solarium use for skin cancer prevention” because new studies have convincingly demonstrated causality. This minireview aims to investigate whether those demands are sufficiently supported by present scientific knowledge and comply with the principles of evidence-based medicine. Materials and Methods: We performed a systematic literature search (through June 2019; PubMed, ISI Web of Science) to identify publications investigating how solarium use affects melanoma risk. Results: We found no studies that demonstrate a causal relationship between moderate solarium use and melanoma risk. Results of cohort and case–control studies published to date, including recent investigations, do not prove causality, and randomized controlled trials providing unequivocal proof are still lacking. Moreover, the overall quality of observational studies is low as a result of severe limitations (including unobserved or unrecorded confounding), possibly leading to bias. We also disagree with recent claims that Hill's criteria for the epidemiological evidence of a causal relationship between a potential causal factor and an observed effect are fulfilled in regard to the conclusion that moderate solarium use per se would increase melanoma risk Conclusion: Current scientific knowledge does not demonstrate a causal relationship between moderate solarium use and melanoma risk. Therefore, the debate is not closed.