PT  - JOURNAL ARTICLE
AU  - KAZU SHIOMI
AU  - SATOKO SHIOMI
AU  - YUJI ISHINAGA
AU  - MOTOKI SAKURABA
AU  - YOSHIAKI HAGIWARA
AU  - KAZUYA MIYASHITA
AU  - MASAHIRO MAEDA
AU  - KENJI SUZUKI
AU  - KAZUHISA TAKAHASHI
AU  - OKIO HINO
TI  - Impact of Renal Failure on the Tumor Markers of Mesothelioma, N-ERC/Mesothelin and Osteopontin
DP  - 2011 Apr 01
TA  - Anticancer Research
PG  - 1427--1430
VI  - 31
IP  - 4
4099  - http://ar.iiarjournals.org/content/31/4/1427.short
4100  - http://ar.iiarjournals.org/content/31/4/1427.full
SO  - Anticancer Res2011 Apr 01; 31
AB  - Background: Knowledge of the characteristics and effective use of tumour markers for mesothelioma is essential for early-stage diagnosis of mesothelioma. We examined whether renal dysfunction influences blood concentrations of promising new tumour markers, N-ERC/mesothelin (N-ERC) and osteopontin (OPN), to an important degree. Patients and Methods: Levels of serum N-ERC and plasma OPN in 32 patients with chronic renal dysfunction, 22 of whom were on hemodialysis (CKD group), and 102 healthy volunteers were measured. Results: Serum concentrations of N-ERC and plasma concentrations of OPN in the CKD group were significantly higher than those in volunteers, regardless of diabetes status and age. Blood concentrations of these markers increased as renal function decreased. Conclusion: N-ERC and OPN concentrations are significantly influenced by renal function. Therefore, the extent of renal failure must be considered when inferring the existence of tumours and chemotherapeutic response from the values of these markers in routine practice.