RT Journal Article SR Electronic T1 Solitary Cerebral Metastases vs. High-grade Gliomas: Usefulness of Two MRI Signs in the Differential Diagnosis JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 4905 OP 4909 DO 10.21873/anticanres.13677 VO 39 IS 9 A1 CARMINE FRANCO MUCCIO A1 ENRICO TEDESCHI A1 LORENZO UGGA A1 RENATO CUOCOLO A1 GENNARO ESPOSITO A1 FERDINANDO CARANCI YR 2019 UL http://ar.iiarjournals.org/content/39/9/4905.abstract AB Background/Aim: The differentiation between cerebral metastases (CM) and high-grade gliomas (HGG) can be difficult on magnetic resonance imaging (MRI). The aim of this study was to evaluate the usefulness of searching two MRI signs (signal alteration in the adjacent cortex, SAAC, and peripheral rim sign, PRS), in order to distinguish between these entities. Patients and Methods: A total of 61 patients were retrospectively enrolled (28 HGG, 33 CM). Fluid Attenuated Inversion Recovery (FLAIR) sequences were used to assess SAAC and contrast-enhanced T1-weighted sequences for PRS. Results: A positive SAAC sign was present in 61% of HGG, and 12% of CM. Conversely, in SAAC-negative lesions, PRS was observed in 78% of CM and in 32% of HGG. Their association had a higher frequency in HGG than in the CM group (21 vs. 3%). Conclusion: While SAAC is specific for HGG and PRS, in the absence of SAAC, is relatively specific for CMs, their combined presence is highly suggestive of HGG.