RT Journal Article
SR Electronic
T1 Relevance of Vitamin D in Melanoma Development, Progression and Therapy
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 473
OP 489
DO 10.21873/anticanres.13976
VO 40
IS 1
A1 ANNA A. BROŻYNA
A1 ROBERT M. HOFFMAN
A1 ANDRZEJ T. SLOMINSKI
YR 2020
UL http://ar.iiarjournals.org/content/40/1/473.abstract
AB Melanoma is one of the most lethal types of skin cancer, with a poor prognosis once the disease enters metastasis. The efficacy of currently available treatment schemes for advanced melanomas is low, expensive, and burdened by significant side-effects. Therefore, there is a need to develop new treatment options. Skin cells are able to activate vitamin D via classical and non-classical pathways. Vitamin D derivatives have anticancer properties which promote differentiation and inhibit proliferation. The role of systemic vitamin D in patients with melanoma is unclear as epidemiological studies are not definitive. In contrast, experimental data have clearly shown that vitamin D and its derivatives have anti-melanoma properties. Furthermore, molecular and clinicopathological studies have demonstrated a correlation between defects in vitamin D signaling and progression of melanoma and disease outcome. Therefore, adequate vitamin D signaling can play a role in the treatment of melanoma.