@article {WILSON5083, author = {ASHLEY WILSON and JAMES SMALL and CATHERINE FLANAGAN and DAVID PERRY and RICHARD MARCHELL and BRUCE THIERS and ANTHONY J. ALBERG}, title = {Keratinocyte Carcinoma and Risk for Another Type of Cancer: Assessment of a Dose-response Relationship}, volume = {39}, number = {9}, pages = {5083--5087}, year = {2019}, doi = {10.21873/anticanres.13702}, publisher = {International Institute of Anticancer Research}, abstract = {Background/Aim: Keratinocyte carcinoma (KC) is a marker of increased risk of other cancer types. To assess if this association exhibits a dose-response relationship, a case-control study was carried out. Patients and Methods: This was a clinic-based study of cases with KC plus another type of cancer matched by age, race (all Caucasian), sex and histologic type to controls with KC only (n=48 matched pairs). Results: Compared with the KC only group, those with KC plus another cancer had a mean number of lesions that were 43\%, 35\%, and 41\% greater for basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and total KC, respectively. The odds ratio (OR) of developing another type of cancer increased from 1.0 to 1.09 (95\% confidence interval (CI)=0.23-5.13) to 2.12 (95\%CI=0.50-9.08) according to whether the patient had zero, one, or >=two BCC lesions; for SCC, the corresponding ORs were 1.0, 1.24 (95\%CI=0.48-3.24), and 1.39 (95\%CI=0.29-6.61). Conclusion: A dose-response relationship seems to exist between the number of skin lesions and the risk of another type of cancer, but the lack of statistical significance weakens this evidence.}, issn = {0250-7005}, URL = {https://ar.iiarjournals.org/content/39/9/5083}, eprint = {https://ar.iiarjournals.org/content/39/9/5083.full.pdf}, journal = {Anticancer Research} }