TY - JOUR T1 - Evaluation of Concordance Between Histopathological, Radiological and Biomolecular Variables in Breast Cancer Neoadjuvant Treatment JF - Anticancer Research JO - Anticancer Res SP - 281 LP - 286 DO - 10.21873/anticanres.13950 VL - 40 IS - 1 AU - ORESTE CLAUDIO BUONOMO AU - ANDREA GRASSO AU - CHIARA ADRIANA PISTOLESE AU - LUCIA ANEMONA AU - ILARIA PORTARENA AU - ROSARIA MEUCCI AU - LJUBA MORANDO AU - CAMILLA DEIANA AU - MARCO MATERAZZO AU - GIANLUCA VANNI Y1 - 2020/01/01 UR - http://ar.iiarjournals.org/content/40/1/281.abstract N2 - Background/Aim: Neoadjuvant chemotherapy (NAC) for breast cancer (BC) is the gold standard treatment for locally advanced tumors (LABC) that aims at achieving a complete pathological response (pCR). Studies have been conducted to evaluate and identify te concordance between radiological, histopathological and biological variables of BC and final response to therapy, verified by definitive histological examination after surgery. Patients and Methods: Ninety-five BC patients were examined and subjected to NAC. Immunohistochemical markers including oestrogen-receptor (ER), progesterone-receptor (PR), Ki67 index, and human epidermal growth factor receptor 2 (HER2) score were examined before and after neoadjuvant treatment. Results: Younger age and a significant decrease in ER expression were associated with better prognosis. Triple Negative (TN) and Her2-type breast cancers benefited most from neoadjuvant chemotherapy with higher frequency of pCR. Conclusion: HER2-type and TN BC are correlated with best response to NAC. A statistically significant correlation between radiological images and definitive histological examination was not observed. ER -