TY - JOUR T1 - Prognostic Value of Hematological Parameters in Locally Advanced Cervical Cancer Patients Treated With Concurrent Chemoradiotherapy JF - Anticancer Research JO - Anticancer Res SP - 451 LP - 458 DO - 10.21873/anticanres.13973 VL - 40 IS - 1 AU - HYUN JUNG LEE AU - JONG MI KIM AU - YOO JEONG CHIN AU - GUN OH CHONG AU - SHIN-HYUNG PARK AU - YOON HEE LEE AU - DAE GY HONG AU - YOON SOON LEE Y1 - 2020/01/01 UR - http://ar.iiarjournals.org/content/40/1/451.abstract N2 - Background/Aim: We evaluated the clinical implications of pre- and post-treatment hematological parameters as prognostic factors in patients with locally advanced cervical cancer (LACC) who received definitive concurrent chemoradiotherapy (CCRT). Patients and Methods: We retrospectively analyzed 125 patients with LACC (FIGO stage IIB to IIIB) who received definitive CCRT. Clinical factors and hematological parameters, including neutrophil-to-lymphocyte ratio (NLR) were assessed pre- and post-CCRT. Univariate and multivariate analysis for disease-free survival (DFS) and overall survival (OS) were performed using clinicopathological and hematological parameters. Results: Disease recurred in 46 (36.8%) patients, and 24 patients (19.2%) died. On multivariate analysis, post-treatment NLR, ΔNLR (pre-treatment NLR/post-treatment NLR) and ΔPLR (platelet-to-lymphocyte ratio) (pretreatment PLR/post-treatment PLR) were significant prognostic factors for DFS, and only post-treatment NLR was a significant prognostic factor for OS (p<0.001). However, pre-treatment hematological parameters were not associated with prognosis. Conclusion: Post-treatment hematological parameters, particularly NLR, may serve as a prognostic indicator in patients with LACC who received definitive CCRT. ER -