PT  - JOURNAL ARTICLE
AU  - SHIRVANI, ARASH
AU  - PERSONS, KELLY S.
AU  - HOLICK, MICHAEL F.
TI  - Evaluation of Effectiveness of Ultraviolet Emitting Lamps on the Cutaneous Production of Vitamin D<sub>3</sub>: Relationship of the Lamps Vitamin D<sub>3</sub> Producing Potential to the Production of 8-Hydroxy-2’-Deoxyguanosine and Nitric Oxide
AID  - 10.21873/anticanres.13986
DP  - 2020 Jan 01
TA  - Anticancer Research
PG  - 565--572
VI  - 40
IP  - 1
4099  - http://ar.iiarjournals.org/content/40/1/565.short
4100  - http://ar.iiarjournals.org/content/40/1/565.full
SO  - Anticancer Res2020 Jan 01; 40
AB  - Background/Aim: To assess the effectiveness of three UV emitting lamps on the cutaneous production of vitamin D3, a marker of DNA damage and nitric oxide production in human skin. Materials and Methods: Human skin samples (skin types II, III and IV) obtained from surgery were exposed to three different UV emitting lamps for varying times and then extracted and chromatographed to determine the vitamin D3 content. The skin samples exposed to the 3 UV emitting lamps were also evaluated for 8-hydroxy-2’-deoxyguanosine (a marker of DNA damage) and nitric oxide production. Results: It was observed that the spectral output of the 3 lamps had different effects on the cutaneous production of vitamin D3, 8-hydroxy-2’-deoxyguanosine and nitric oxide production. One lamp demonstrated optimal production of vitamin D3 with the least amount of DNA damage and intermediate production of nitric oxide suggesting that it could be developed into a device for treating vitamin D deficiency. Conclusion: The spectral output of the experimental UVB emitting lamps significantly influenced the cutaneous production of vitamin D3 8-hydroxy-2’-deoxyguanosine and nitric oxide.