RT Journal Article
SR Electronic
T1 The FSHR Expression in Head and Neck Squamous Cell Cancer. A Pilot Immunohistochemical Study
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 349
OP 356
DO 10.21873/anticanres.13959
VO 40
IS 1
A1 TOMAS OLEJAR
A1 DAVID VETVICKA
A1 JAN BOUCEK
A1 MICHAL ZABRODSKY
A1 JIRI BENES
A1 MARTINA KABESOVA
A1 PAVLA POUCKOVA
YR 2020
UL http://ar.iiarjournals.org/content/40/1/349.abstract
AB Background/Aim: Follicle-stimulating hormone receptor (FSHr), expressed on endothelial cells of vessels in different malignant tumors, has been recently investigated as a potential pan-receptor of cancer treatment. However, the expression of this receptor has also been confirmed in other tissues under pathological conditions including cancer. The aim of the presented pilot study was to evaluate the expression of FSHr in head and neck squamous cancer (HNSCC). Patients and Methods: A total of 28 HNSCC patient samples were immunohistochemically analyzed for the presence of FSHr using a commercially available primary antibody. Results: FSHr was detected not only in the tumor tissue, but also in the basal layer or dysplastic parts of squamous mucosa and also in fibroblasts surrounding the tumor tissue. Conclusion: FSHr is present on different benign or malignant mesenchymal and epithelial structures in HNSCC. A brief literature review revealed a wider role of FSHr in the development of neoplasia.