TY - JOUR T1 - The FSHR Expression in Head and Neck Squamous Cell Cancer. A Pilot Immunohistochemical Study JF - Anticancer Research JO - Anticancer Res SP - 349 LP - 356 DO - 10.21873/anticanres.13959 VL - 40 IS - 1 AU - TOMAS OLEJAR AU - DAVID VETVICKA AU - JAN BOUCEK AU - MICHAL ZABRODSKY AU - JIRI BENES AU - MARTINA KABESOVA AU - PAVLA POUCKOVA Y1 - 2020/01/01 UR - http://ar.iiarjournals.org/content/40/1/349.abstract N2 - Background/Aim: Follicle-stimulating hormone receptor (FSHr), expressed on endothelial cells of vessels in different malignant tumors, has been recently investigated as a potential pan-receptor of cancer treatment. However, the expression of this receptor has also been confirmed in other tissues under pathological conditions including cancer. The aim of the presented pilot study was to evaluate the expression of FSHr in head and neck squamous cancer (HNSCC). Patients and Methods: A total of 28 HNSCC patient samples were immunohistochemically analyzed for the presence of FSHr using a commercially available primary antibody. Results: FSHr was detected not only in the tumor tissue, but also in the basal layer or dysplastic parts of squamous mucosa and also in fibroblasts surrounding the tumor tissue. Conclusion: FSHr is present on different benign or malignant mesenchymal and epithelial structures in HNSCC. A brief literature review revealed a wider role of FSHr in the development of neoplasia. ER -