RT Journal Article
SR Electronic
T1 Expression and Prognostic Impact of VEGF, CD31 and αSMA in Resected Primary Lung Cancers
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 4057
OP 4063
DO 10.21873/anticanres.12695
VO 38
IS 7
A1 KATSUO USUDA
A1 SYUN IWAI
A1 AIKA FUNASAKI
A1 ATSUSHI SEKIMURA
A1 NOZOMU MOTONO
A1 YOSHIMITI UEDA
A1 MIYAKO SHIMAZAKI
A1 HIDETAKA URAMOTO
YR 2018
UL http://ar.iiarjournals.org/content/38/7/4057.abstract
AB Background/Aim: One of the most important factors concerning cancer growth is angiogenesis. The purpose of this study was to clarify the relationship of maturation of tumor vessels and prognosis of lung cancer. Materials and Methods: Immunohistochemical stainings of 125 lung cancers for VEGF, CD31 and α-smooth muscle actin (αSMA) were scored by multiplying the intensity and the frequency from 0 to 12. Results: Adenocarcinomas showed significantly higher staining scores of both VEGF and αSMA than squamous cell carcinomas did. In 42 cases of high CD31 score, five-year survival rate (87%) of patients with lung cancer showing mature tumor vessels was significantly better than that (69%) of patients with immature tumor vessels. Conclusion: Not the number of tumor vessels but their maturation may be a prognostic factor of patients with lung cancer. VEGF may not only stimulate proliferation of endothelial cells but also their maturation in differentiated lung cancers.