RT Journal Article
SR Electronic
T1 The Significance of Molecular Biomarkers on Clinical Survival Outcome Differs Depending on Colon Cancer Sidedness
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 201
OP 211
DO 10.21873/anticanres.13941
VO 40
IS 1
A1 SHO HIRABAYASHI
A1 MASAMICHI HAYASHI
A1 GORO NAKAYAMA
A1 SHINJI MII
A1 NORIFUMI HATTORI
A1 HIROSHI TANABE
A1 MITSURO KANDA
A1 CHIE TANAKA
A1 DAISUKE KOBAYASHI
A1 SUGURU YAMADA
A1 MASAHIKO KOIKE
A1 MICHITAKA FUJIWARA
A1 MASAHIDE TAKAHASHI
A1 YASUHIRO KODERA
YR 2020
UL http://ar.iiarjournals.org/content/40/1/201.abstract
AB Background/Aim: This retrospective study focused on the correlation between molecular markers and prognostic outcomes of colon cancer patients depending on sidedness. Materials and Methods: A total of 117 stage I-III colon cancer patients who underwent colectomy were enrolled. Novel methylation markers (KIF1A, PAX5 and VGF) were selected for epigenetic evaluation and p53 and ERCC1 protein expression was examined for the investigation of genetic alterations. Results: High frequency of methylation was observed in 68.2% of right-sided and 39.7% of left-sided colon cancer cases (p=0.004). Abnormal p53 was identified in 52.3% of right-sided and 75.3% of left-sided cases (p=0.015). In right-sided cases, highly methylated genes demonstrated significantly favorable disease-free survival (p=0.049). Regarding left-sided cases, advanced T stage (p=0.028) and abnormal p53 (p=0.028) were revealed to be significant predictive factors of the disease-free survival outcome. Conclusion: Molecular alterations, as significant prognostic factors, might differ depending on the sidedness of colon cancers.