RT Journal Article
SR Electronic
T1 Increased Risk of Breast and Uterine Cancer Among Women With Ovarian Granulosa Cell Tumors
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 4971
OP 4975
DO 10.21873/anticanres.13686
VO 39
IS 9
A1 NASIOUDIS, DIMITRIOS
A1 WILSON, ELISE
A1 MASTROYANNIS, SPYRIDON A.
A1 SISTI, GIOVANNI
A1 HAGGERTY, ASHLEY F.
A1 KO, EMILY M.
A1 LATIF, NAWAR A.
YR 2019
UL http://ar.iiarjournals.org/content/39/9/4971.abstract
AB Background/Aim: We evaluated the incidence of uterine and breast cancer among women diagnosed with granulosa cell tumors (GCTs) of the ovary. Patients and Methods: The US Surveillance, Epidemiology, and End Results (SEER) database was accessed and patients diagnosed with a GCT and had a known follow-up between 1973-2014 were identified. Personal tumor history was extracted and patients with a previous or subsequent malignant breast or uterine tumor were identified. The expected incidence of breast and uterine cancer was calculated based on the U.S age-specific rate of breast and uterine cancer per 100,000 women. Standardized incidence ratio (SIR) with 95% confidence intervals (95% CI) were calculated for each tumor. Results: A total of 1908 cases of GCT were identified. Seventy- nine (4.14%) and 53 (2.78%) patients were diagnosed with a malignant breast and uterine malignancy. The cumulative expected number of malignant breast and uterine tumors was 27 (1.41%) and 6 (0.31%), respectively. The calculated SIR for breast and uterine malignancies was 2.96 (95%CI=2.34, 3.68) and 8.83 (95%CI=6.61, 11.56), respectively. Conclusion: An increased incidence of breast and uterine malignancies among patients diagnosed with GCTs was observed.