PT  - JOURNAL ARTICLE
AU  - NASIOUDIS, DIMITRIOS
AU  - WILSON, ELISE
AU  - MASTROYANNIS, SPYRIDON A.
AU  - SISTI, GIOVANNI
AU  - HAGGERTY, ASHLEY F.
AU  - KO, EMILY M.
AU  - LATIF, NAWAR A.
TI  - Increased Risk of Breast and Uterine Cancer Among Women With Ovarian Granulosa Cell Tumors
AID  - 10.21873/anticanres.13686
DP  - 2019 Sep 01
TA  - Anticancer Research
PG  - 4971--4975
VI  - 39
IP  - 9
4099  - http://ar.iiarjournals.org/content/39/9/4971.short
4100  - http://ar.iiarjournals.org/content/39/9/4971.full
SO  - Anticancer Res2019 Sep 01; 39
AB  - Background/Aim: We evaluated the incidence of uterine and breast cancer among women diagnosed with granulosa cell tumors (GCTs) of the ovary. Patients and Methods: The US Surveillance, Epidemiology, and End Results (SEER) database was accessed and patients diagnosed with a GCT and had a known follow-up between 1973-2014 were identified. Personal tumor history was extracted and patients with a previous or subsequent malignant breast or uterine tumor were identified. The expected incidence of breast and uterine cancer was calculated based on the U.S age-specific rate of breast and uterine cancer per 100,000 women. Standardized incidence ratio (SIR) with 95% confidence intervals (95% CI) were calculated for each tumor. Results: A total of 1908 cases of GCT were identified. Seventy- nine (4.14%) and 53 (2.78%) patients were diagnosed with a malignant breast and uterine malignancy. The cumulative expected number of malignant breast and uterine tumors was 27 (1.41%) and 6 (0.31%), respectively. The calculated SIR for breast and uterine malignancies was 2.96 (95%CI=2.34, 3.68) and 8.83 (95%CI=6.61, 11.56), respectively. Conclusion: An increased incidence of breast and uterine malignancies among patients diagnosed with GCTs was observed.