%0 Journal Article %A MING-HSIEN WU %A HUEY-EN TZENG %A CHENG-NAN WU %A TE-CHENG YUEH %A YEN-CHUN PENG %A CHUN-HAO TSAI %A YUN-CHI WANG %A TAO-WEI KE %A JEN-SHENG PEI %A WEN-SHIN CHANG %A CHIA-WEN TSAI %A DA-TIAN BAU %T Association of Matrix Metalloproteinase-9 rs3918242 Promoter Genotypes With Colorectal Cancer Risk %D 2019 %R 10.21873/anticanres.13867 %J Anticancer Research %P 6523-6529 %V 39 %N 12 %X Background/Aim: Matrix metalloproteinase-9 (MMP-9) is responsible for modifying extracellular components and plays a crucial role in the metastatic behavior of cancer. This study aimed at examining the role of MMP-9 rs3918242 genotypes on colorectal cancer (CRC) risk. Materials and Methods: A total of 362 CRC patients and 362 healthy subjects in Taiwan, were examined by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methodology. Results: The MMP-9 rs3918242 TT genotype carriers had a slightly increased risk of CRC compared to CC carriers (p=0.1642, OR=1.88, 95% CI=0.84-4.16). Patients of CT/TT genotypes were on significantly higher risk of metastasis (p=0.0027) than those of CC genotype. No obvious association was found between MMP-9 genotype and CRC risk among ever-smokers, non-smokers, non-alcohol drinkers or alcohol drinkers. No significant correlation was observed between MMP-9 genotypic distributions with age, gender, tumor size or location. Conclusion: MMP-9 rs3918242 genotypes may interact with BMI to serve as a predictor for higher CRC risk, and independently as a predictor for metastasis. %U https://ar.iiarjournals.org/content/anticanres/39/12/6523.full.pdf