RT Journal Article
SR Electronic
T1 Allogeneic Venous Grafts of Different Origin Used for Portal Vein Reconstruction After Pancreaticoduodenectomy – Experimental Study
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 6603
OP 6620
DO 10.21873/anticanres.13876
VO 39
IS 12
A1 PALEK, RICHARD
A1 JONASOVA, ALENA
A1 ROSENDORF, JACHYM
A1 MIK, PATRIK
A1 BAJCUROVA, KRISTYNA
A1 HOSEK, PETR
A1 MOULISOVA, VLADIMIRA
A1 EBERLOVA, LADA
A1 HAIDINGEROVA, LENKA
A1 BRZON, ONDREJ
A1 BEDNAR, LUKAS
A1 KRIZ, TOMAS
A1 DOLANSKY, MARTIN
A1 TRESKA, VLADISLAV
A1 TONAR, ZBYNEK
A1 VIMMR, JAN
A1 LISKA, VACLAV
YR 2019
UL http://ar.iiarjournals.org/content/39/12/6603.abstract
AB Background: In clinical medicine, little is known about the use of allografts for portal vein (PV) reconstruction after pancreaticoduodenectomy (PD). Portal and caval systems are physiologically different, therefore the properties of allografts from caval and portal systems were studied here in a pig model. Materials and Methods: PD with PV reconstruction with allogeneic venous graft from PV or inferior vena cava (IVC) was performed in 26 pigs. Biochemical analysis and ultrasonography measurements were performed during a 4-week monitoring period. Computer simulations were used to evaluate haemodynamics in reconstructed PV and explanted allografts were histologically examined. Results: The native PV and IVC grafts varied in histological structure but were able to adapt morphologically after transplantation. Computer simulation suggested PV grafts to be more susceptible to thrombosis development. Thrombosis of reconstructed PV occurred in four out of five cases in PV group. Conclusion: This study supports the use of allografts from caval system for PV reconstruction in clinical medicine when needed.