PT  - JOURNAL ARTICLE
AU  - PALEK, RICHARD
AU  - JONASOVA, ALENA
AU  - ROSENDORF, JACHYM
AU  - MIK, PATRIK
AU  - BAJCUROVA, KRISTYNA
AU  - HOSEK, PETR
AU  - MOULISOVA, VLADIMIRA
AU  - EBERLOVA, LADA
AU  - HAIDINGEROVA, LENKA
AU  - BRZON, ONDREJ
AU  - BEDNAR, LUKAS
AU  - KRIZ, TOMAS
AU  - DOLANSKY, MARTIN
AU  - TRESKA, VLADISLAV
AU  - TONAR, ZBYNEK
AU  - VIMMR, JAN
AU  - LISKA, VACLAV
TI  - Allogeneic Venous Grafts of Different Origin Used for Portal Vein Reconstruction After Pancreaticoduodenectomy – Experimental Study
AID  - 10.21873/anticanres.13876
DP  - 2019 Dec 01
TA  - Anticancer Research
PG  - 6603--6620
VI  - 39
IP  - 12
4099  - http://ar.iiarjournals.org/content/39/12/6603.short
4100  - http://ar.iiarjournals.org/content/39/12/6603.full
SO  - Anticancer Res2019 Dec 01; 39
AB  - Background: In clinical medicine, little is known about the use of allografts for portal vein (PV) reconstruction after pancreaticoduodenectomy (PD). Portal and caval systems are physiologically different, therefore the properties of allografts from caval and portal systems were studied here in a pig model. Materials and Methods: PD with PV reconstruction with allogeneic venous graft from PV or inferior vena cava (IVC) was performed in 26 pigs. Biochemical analysis and ultrasonography measurements were performed during a 4-week monitoring period. Computer simulations were used to evaluate haemodynamics in reconstructed PV and explanted allografts were histologically examined. Results: The native PV and IVC grafts varied in histological structure but were able to adapt morphologically after transplantation. Computer simulation suggested PV grafts to be more susceptible to thrombosis development. Thrombosis of reconstructed PV occurred in four out of five cases in PV group. Conclusion: This study supports the use of allografts from caval system for PV reconstruction in clinical medicine when needed.