RT Journal Article SR Electronic T1 Establishment of Drug-resistant Cell Lines as a Model in Experimental Oncology: A Review JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 6443 OP 6455 DO 10.21873/anticanres.13858 VO 39 IS 12 A1 MÁRCIA VANESSA SALES AMARAL A1 ADRHYANN JULLYANNE DE SOUSA PORTILHO A1 EMERSON LUCENA DA SILVA A1 LÍVIA DE OLIVEIRA SALES A1 JERSEY HEITOR DA SILVA MAUÉS A1 MARIA ELISABETE AMARAL DE MORAES A1 CAROLINE AQUINO MOREIRA-NUNES YR 2019 UL http://ar.iiarjournals.org/content/39/12/6443.abstract AB Many types of cancer are initially susceptible to chemotherapy, but during treatment, patients may develop resistance to therapy. Knowing that acquisition of drug resistance is a major clinical problem in antineoplastic treatment, the present work aimed to present, through a literature review, the development of chemoresistant cells lines as a model in experimental oncology. A total of 110 drug-resistant cell lines, mainly from lung tumors and leukemias, have been developed. In addition, it has been observed that the drugs used for induction of resistance represented the drugs used for first-line treatment of each neoplasia, since the ideal chemotherapeutic treatment to induce resistance in vitro aims at a better modulation of the therapeutic response in order to better study the mechanisms of resistance.